
Naftopidil hydrochloride
CAS No. 1164469-60-6
Naftopidil hydrochloride( KT-611 hydrochloride | BM-15275 hydrochloride | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3- )
Catalog No. M23339 CAS No. 1164469-60-6
Naftopidil hydrochloride is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 78 | In Stock |
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5MG | 118 | In Stock |
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10MG | 178 | In Stock |
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25MG | 320 | In Stock |
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50MG | 480 | In Stock |
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100MG | 692 | In Stock |
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500MG | 1422 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameNaftopidil hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionNaftopidil hydrochloride is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively.
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DescriptionNaftopidil hydrochloride is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
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In VitroNaftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC. Cell Proliferation Assay Cell Line:PCa cells, PrSC Concentration:10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC) Incubation Time:3 days Result:Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.Western Blot Analysis Cell Line:PCa cells, PrSC Concentration:50 μM (E9 cells), 25 μM (PrSC)Incubation Time:48 hours Result:Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
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In VivoNaftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model. Animal Model:Male athymic mice(7-8 weeks), with E9+PrSC xenograft Dosage:10 mg/kg Administration:Oral administration, daily, for 28 days Result:Decreased tumor weights.
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SynonymsKT-611 hydrochloride | BM-15275 hydrochloride | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-
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PathwayApoptosis
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TargetAdenosine Receptor
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Recptorα1-adrenoceptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1164469-60-6
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Formula Weight428.95
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Molecular FormulaC24H29ClN2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESOC(COC1=C2C=CC=CC2=CC=C1)CN3CCN(C4=CC=CC=C4OC)CC3.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Urushiyama H , Y Terasaki, Nagasaka S , et al. Naftopidil reduced the proliferation of lung fibroblasts and bleomycin﹊nduced lung fibrosis in mice[J]. Journal of Cellular and Molecular Medicine, 2019.
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